SAFE® Capper & Decapper Systems FAQ –
Manual to Fully Automated Capping

SAFE® systems are available in manual, semi-automated, and fully automated variants.

Depending on the application, individual tubes or complete SBS racks (24-, 48-, or 96-format) can be opened or closed simultaneously.

Manual systems are operated by hand and are suitable for smaller sample volumes or flexible lab environments.

Automated systems are motor-driven with defined torque, providing consistent, reproducible clamping force regardless of the operator.

Semi-automated systems combine manual positioning with controlled mechanics.

They are ideal for labs with medium sample throughput, where higher reproducibility than purely manual systems is required.

Controlled torque ensures that each screw cap is closed with consistent clamping force.

The sealing of SAFE® 2D tubes was validated at a defined torque of 7 Ncm (for SBS 96) and 15 Ncm (for SBS 48 and SBS 24).

Reproducible torque reduces the risk of micro-leakage or inconsistent closures.

For cryogenic applications down to −196 °C, stable clamping force is critical.

Validation tests included 15 automated open/close cycles, showing:

• No leakage
• No seal surface damage
• No thread wear

Combined with the axial TPE sealing system, controlled capping supports long-term cryo-stability.

Multi-channel or rack cappers provide uniform clamping force across all positions.

This reduces the risk of insufficiently sealed tubes and supports consistent workflows, particularly in automated processes.

Multi-channel systems (e.g., 4-, 6-, or 8-channel) allow simultaneous capping of multiple 2D sample tubes.

This increases efficiency and ensures uniform clamping force within an SBS rack.

Yes.

Special rack cappers and decappers are designed for 24-, 48-, or 96-position racks, allowing simultaneous handling of all tubes in a rack.

SAFE® systems are tailored to the respective thread types.

Internal and external threads require technically adapted mechanisms to ensure optimal sealing and material protection.

Yes.

Fully automated capper and decapper systems can be integrated into robotic processes, automated storage systems, and liquid-handling platforms.

SBS standardization of tubes and racks is a key prerequisite.

Automated systems operate with defined torque and reduce manual variability.

This increases reproducibility in high-throughput environments and supports stable processes in GMP-adjacent workflows.

In high-throughput screenings, large sample volumes need to be processed efficiently.

Automated decappers allow simultaneous opening of entire SBS racks, accelerating pipetting or transfer workflows.

Multi-channel or motorized systems reduce repetitive hand movements.

This lowers physical strain and supports consistent operation quality.

Selection depends on:

• Sample throughput
• Level of automation
• Cryogenic application
• Regulatory requirements

For long-term LN₂ applications, systems with controlled torque are preferred.

SAFE® components have been validated as a complete tube–cap–rack system.

Coordinated system geometry reduces potential interface risks such as:

• Inconsistent thread tolerances
• Variable sealing forces
• Rack position deviations

This is particularly relevant in automated high-throughput environments.